Microsoft Releases Updated Microsoft Baseline Configuration Analyzer 2.0

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Running head: Assignment 3





ASSIGNMENT 3: MICROBIOLOGY
 
Table of Contents
Question 1 3
Question 2 3
Question 3 6
Question 4 6
Question 5 7
Question 6 8
Question 7 9
Question 8 11
Question 9 12
Question 10 12
Question 11 13
Question 12 14
Question 13 14

 
Question 1
An enveloped virus consists of the nucleic acid and the helical and the polyhedral core mainly covered by the envelope. Complex or Binal viruses do not have the polyhedral and the helical form. In another hand, it has irregular shapes. Hence it also has complex structures. Moreover, the viruses have constricted as infectious agents. Hence it plays the leading role in spreading the infections. These agents are the infectious agents and have the nonliving and living characteristics. Viruses are mostly smaller in size than the bacteria helical viruses are generally surrounded by the hollow protein capsid. Hence it is the pivotal factor which process in the helical structure. Polyhedral Viruses mainly consists of the nucleic acid and it mainly surrounded by the many-sided shell. Hence usually it reforms the icosahedrons. Enveloped viruses contain the nucleic acid and it mainly surrounded by the polyhedral core. Thus it covered by the envelope. Complex viruses have complex structures. The complex ruses process the capsidence it neither the part of the icosahedra or the helical. It may have extensive structures like the protein tails. Hence it had constricted as the complex outer wall.
Question 2
a.

Figure1: The diagram of bacteriophage (Labelled with Sheath, capsid, baseplate, and tail fibres, nucleic acid)

b.

Figure 2: The graph over bacteriophage A and bacteriophage B
i. According to the above diagram, it has been understood that, the sample of E. coli as a host organism mixed with each step. After that, it was distributed on the molten agar. In terms of agar, it incubated for 3 hours and each hours pfu/mL was recorded.
ii. In accordance with figure 2, it is seen that Phage A was more efficient rather than Phage B. Both phage A and B was poured into a plate contained host bacterium, Phage A and E. coli. After 1 hour more viruses were produced respectively. In this regard, it also tended emphasizing on Phage A in which a large number of host cells were infected. It is worth to mention that, while a host bacterium or cell gets infected by viruses, it could be multiplied and released thousands of more viruses that also observed in Phage A. However, Phage B has limitation to release 40 viruses that are not efficient as represented in figure 2.
iii. The scientists use the phages in the research works considering the therapeutic characteristics of the phage. The phages might able treating the bacterial infections to which it contributes the area of phage therapy. Phages contain the ability to destroy host cells. Also, it includes slow host ranging. The phages could infect upon the bacteria that are involved in the bacterial infection. For example, human. Therefore, in terms of theory, phages are seen as capable of treating bacterial infections in humans without affecting them.

Question 3
Poxviridae is the family of the viruses. The anthropoids serve as the natural host. There are mostly about 69 species in the family. Hence it divided into 28 genera. Thus it divided into two subfamilies. The major disease associated with the family consists of smallpox. Four genera in the context of the poxviruses are parapoxvirus, orthopoxvirus, yatapoxvirus, molluscipoxvirus.
Question 4
a.
The patient has mentioned that the Microbiological examination had indicated the patient has been infected by the Salmonella. It also has observed during this hospitalization course the patient has been treated by the quinolone antibiotic. Hereby, the organism numerical value have monitored during the hospitalization. Hereby, the salmonella has confined as the bacterial disease and this affects the intestinal tract. Salmonella bacteria live in the human intestines. Furthermore, it shed by the feces. The disease mainly infected human-beings by the contaminated food or fluid. The first stage of the Salmonella includes the disease such as diarrhea, vomiting, fever, abdominal cramps. The abdominal cramps occurred after the 12-72 hours of the food infection as well as salmonella. Diarrhea is non-bloody and watery. However, it may be bloody and mucoid. The person with a weak immune system mostly develops this disease within a short span of time.
b.
Hereby, the patient has developed Salmonnell a disease as well as the food poisoning. The causative agent is the distinct bacteria in the context f the genus Salmonella. This causes diarrheal illness and sometimes it causes the septicemia. Salmonella enteritidis had constricted as the causative agent to influence the foodborne gastrointestinal illness.
Avoiding the foods which put the high risk for the salmonella infection have identified as the major preventing way. Keeping the food in the average temperature in the refrigerator. Hence it can raise the prevention from the salmonella.
Question 5

Column A Column B
pandemic disease World-wide effects
septicemia Causes fever
nosocomial Infection Hospital-acquired
prodromal Period early symptoms of infection
acute disease infection that lasts for a brief period
epidemic disease afflicts large numbers of people
pathology of disease cause of disease
incidence symptoms
aetiology of disease number of people infected during a particular time period
not spread from one host to another non-communicable disease


Question 6
a. Injecting the group of cows seems virulent because of its lower concentration of 103. The cows infected for opposing the cows those were infected through aerosol. Besides, a large number of cows infected due to the overall injection. It is noteworthy that, the dose of infections is less than the process of aerosol. Hence, injected is effectively virulent.
ID50=104(injected cows)
ID50=106 (exposed cows to aerosol)
b. A large number of cows were seen to be injected due to the dose of injection rather than the aerosol infection. Overall 24 cows were infected by the injection and rest 9 cows were infected by the method of aerosol at the entire concentrations. Excluding 0, all of the concentrations, the injection affected the maximum cows to get infected than the process of aerosol. Besides, the low concentration of 103, only the injected cows were infected whereas excluding the cows treated with aerosol.
c. The researchers could utilize a similar experimental procedure for examining the lethal dosages. However, keeping up the increased concentration until half of the cows get died. The lethal dose will measure the dead of the organism at LD50.
d. Administrating the vaccine (FMDV) to all of the involved cows as well as repeating the experimental process need to be continued. It will increase the dose with ID50 that has been previously determined in question b. after that, it requires to keep up the new determined ID50 through the vaccine. At ID50, the significant of the organism will be observed to decrease the rate of infection. However, it will be only observed if the vaccine works. Apart from that, another vaccine method needs to be formulated while the dose of vaccine fails to work.
Question 7

Virulence Factor
Function or Effect on the Host
Example of a Bacterium that Produces it
Benefit for the Bacterium

Adhesin




Allows the bacterium for adjourning to target and hosts particular receptors Listeria monocytogenes It is used to adhere and could be an aid in formulated biofilm,. Besides, it increases the virulence of the bacterium
Capsule It resists the defences of the hosts through impairing the phagocytosis Streptococcus pneumonia It permits the bacterium while increasing the virulence

M protein
It mediated the bacterium attachment to host epithelial cells. Also, it helps in bacterium resistance phagocytosis by the while host blood cells Streptococcus pyogenes The acid-resistant as well as heat resistant protein that increases the virulence of the microorganisms
Hyaluronidase
It is an enzyme that hydrolyses the hyaluronic acid. The hyaluronic acid is considered a polysaccharide in which the certain cells are held together. Streptococcus pyogenes It helps to spread the bacterium from the primary infected sites to other places
Exotoxin
It can destroy the specific parts of inhibited certain functions of metabolism or the host cells Clostridium botulinum Exotoxins are generally proteins. However, there are a wide amount of exotoxin enzymes exist that catalyzes that the particular biochemical reactions

Question 8
Immunity is a term which is naturally present in every human body Hough the level is different for everyone. Thus it cannot be referred sensitize priorly rather t ios an antigen from vaccination or infection. As the specific antigens do not stimulate it thereby innate immunity is referred to as nonspecific. In contrast, it is acquired immunity thus can be referred to as natural immunity.
The Mucosal innate immune system plays the role of eliminating and sensing pathogens and even helps in creating symbiosis. The first biochemical and physical barrier is tye epithelium which is covered by the mucous layer. The mucosal immune system is adjacent with unique innate along with defence mechanisms through the protection is offered its first step against inhaled and ingested infectious agents.
Question 9
Fever is referred to as a non-specific defence as it gets develope through the interaction of different other traumas. Circulation of substances like called pyrogens is the main source of fever as the former first affect the hypothalamus of the brain followed by the raising of the temperature. Excessive fever is harmful, however, in general, it plays a beneficial role as separate sensitive micro-organisms can be initiated by the retards of the increased tem[arature which helps to increase the metabolism rate stimulating immunity system
Question 10
Plenty of small proteins are referred to as complement system which is synthesized through the liver and circulate it in the blood as precursors which are inactive. Several triggers are there to stimulate the process.
Deficiency of complement proteins C5b through C9 projects a barrier in killing the bacterias or to suspect it a without the help of other pathways it cannot be able to initiate the process by itself.
Deficiency of the complement protein C5b through C9 projects different bacterial threatening or scopes for infection for a persona in most of the cases it can be seen tat it is associated with Neisseria species which initiate sexually transmitted diseases like gonorrhoea. Further, it can help to form different types of bacterial meningitis.
Question 11

Figure 3: A Typical Antibody Molecule
Question 12

Figure 4: Flow of Virus Infection
The Cytotoxic T Lymphocytes able to destroy the malignant cells as well as virus-infected cells through Apoptosis induction. This kind of cell death can be characterized through several cellular changes which also includes membrane blebbing and shrinkage; DNA fragmentation and chromatin condensation; phosphatidylserine externalization to the outer part of leaflet regarding the plasma membrane as well as the disruption of the inner mitochondrial potential of transmembrane. Generally, the death of cell able to induce by Cytotoxic T Lymphocytes with such biochemical and morphological features, however, such quantitative death may include DNA fragmentation, membrane changes and depolarization of mitochondria.
Question 13
Generally, autoimmune disease is such a condition where our immune system attacks our own body mistakenly. Actually, our immune system forgets to identify the own cells and foreign cells. Therefore, our immune system started to treat our own cells as foreign cells. In the autoimmune disease, our immune system has mistaken our own body parts like skin and joints as foreign.
Example of Autoimmune disease may include Sjogren syndrome, Juvenile or type 1 diabetes etc.

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